ABSTRACT
Chronic pain is a worldwide public health problem in which neuropathic pain (NP) caused by nerve damage is the most common chronic pain. At present, NP lacks effective treatment for any reason. In recent years, increasing studies have shown that neuroimmunity and neuroinflammation play a key role in mediating NP, and nuclear factor-kappa B (NF-κB) plays the most important role in the expression of pain inducers and effectors in the immune and inflammatory systems. NF-κB promotes transcriptional up-regulation by a promoter that links to a variety of inflammatory factors. Therefore, this paper reviews the research status of the role of NF-κB in NP.
ABSTRACT
Chronic pain is a worldwide public health problem in which neuropathic pain (NP) caused by nerve damage is the most common chronic pain.At present,NP lacks effective treatment for any reason.In recent years,increasing studies have shown that neuroimmunity and neuroinflammation play a key role in mediating NP,and nuclear factor-kappa B (NF-κB) plays the most important role in the expression of pain inducers and effectors in the immune and inflammatory systems.NF-κB promotes transcriptional up-regulation by a promoter that links to a variety of inflammatory factors.Therefore,this paper reviews the research status of the role of NF-κB in NP.